Dr. Andrew Lynn

Talk Title:

Using metabolic networks as a base to model microbial populations involved in soil remediation


The remediation of damaged ecological systems through the introduction of appropriate
biological agents is a major requirement. One such aid would be a predictive system that can
list the required biotic agents for remediation. For metabolic mapping of pathways from
known microbial genomes, we use a protocol developed in-house, which uses hidden Markov
models of pre-classified enzyme sequences to accurately predict the enzymatic component of
the genome. The gaps in the reference network, after mapping partial networks of microbial
communities from degraded soil, can be used to list intercalated taxonomic groups
complementing the existing partial metabolic network to predict commensal communities and
a taxonomic composition for a specific set of carbon source and sink metabolites.